Clinicopathological analyses of combined hepatocellular carcinoma and cholangio carcinoma
10.13315/j.cnki.cjcep.2017.05.011
- VernacularTitle:混合细胞型肝癌的临床病理分析
- Author:
Liquan YU
;
Yang WAN
;
Jiangming CHEN
;
Zhongshan YU
;
Peikun LI
;
Shengxue XIE
- Keywords:
hepatic neoplasm;
combined hepatocellular carcinoma-cholangio carcinoma;
clinicopathologitcal characteristics;
immunohistocbemistry
- From:
Chinese Journal of Clinical and Experimental Pathology
2017;33(5):520-524
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinicopathological characteristics and treatment of combined hepatocellular carcinoma-cholangio carcinoma (cHCC-CC).Methods 24 cases of cHCC-CC were collected.The clinical pathological characteristics,imaging,immunophenotyping and clinical features were retrospectively analyzed and reviewed the literature.Results There were 18 males and 6 females in 24 cases of cHCC-CC.The age ranged from 36 to 68 years (mean age was 54.38).Tumour location:right hepatic lobe in 15 cases,left hepatic lobe in 6 cases,both left lobe and right hepatic lobe in 1 case,hepatic caudate and left lateral lobe in 1 case,diffuse nodular liver tumors in 1 case.Grossly,the texture and color of tumor was related to the composition of tumor.Microscopically,classic cHCC-CC had two areas composed of hepatocellular carcinoma area and cholangiocar cinoma area of mixed distribution or migration distribution.3 cases were cHCC-CC with stem cell properties (cholangiolocellular carcinoma type,CLC type).Immunohistochemical staining revealed that HCC like area mainly expressed CD10,CK8,Hepatocyte and CD10,cHCC-CC area expressed CK7 and EMA.CLC type expressed the immunophenotypic features of intermediate type of HCC.Conclusion The clinical manifestations of cHCC-CC are not specific,the preoperative diagnosis is difficult,and it should be combined with pathological characteristics,imaging features and immunophenotype diagnosis.
