Expression and clinical significance of CD47 in triple negative breast carcinoma
10.13315/j.cnki.cjcep.2017.05.015
- VernacularTitle:三阴型乳腺癌中CD47的表达及其临床意义
- Author:
Fan ZHANG
;
Wei ZHANG
;
Nanlin JIAO
;
Xia LIU
;
Ming CAO
;
Guoxiang XU
;
Weixuan ZHANG
- Keywords:
breast neoplasm;
triple negative breast carcinoma;
CD47;
immunohistochemistry;
targeted therapy
- From:
Chinese Journal of Clinical and Experimental Pathology
2017;33(5):539-543
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the expression and clinical significance of CD47 in triple negative breast carcinoma (TNBC),and to analyze the relationship between CD47 expression and clinicopathologic features.Methods Immunohistochemical of Bond Polymer Refine Detection staining was performed on tissue array.It contains 185 cases of TNBC and 35 cases of non triple negative breast carcinoma (NTNBC).Then we observed the expression of CD47 in TNBC,and analyzed the relationship between the expression of CD47 and various clinical pathological characteristics.Results The expression of CD47 in tumor cells of TNBC was higher than that in NTNBC,and the difference was statistically significant (P ＜ 0.05).The CD47 expression rate in TNBC tumors was 52.3％.It was closely related to clinical stage (P ＜ 0.05),lymph node metastasis and distant metastasis (P ＜ 0.05) and vascular invasion (P ＜ 0.05).Conclusion The expression of CD47 is correlated with the clinical stage,lymph node metastasis,distant metastasis and vascular invasion of TNBC.CD47 can be used as a prognostic indicator and a potential target for immune therapy.
