Changes of p62 and XIAP expression after neoadjuvant chemotherapy in breast cancer and their significance
10.13315/j.cnki.cjcep.2017.05.003
- VernacularTitle:乳腺癌新辅助化疗前后p62和XIAP表达的变化及其意义
- Author:
Ying HAN
;
Zhengsheng WU
;
Qiang WU
- Keywords:
breast neoplasm;
neoadjuvant chemotherapy;
autophagy;
apoptosis;
p62;
XIAP
- From:
Chinese Journal of Clinical and Experimental Pathology
2017;33(5):481-484
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the change of autophagy after neoadjuvant chemotherapy (NCT) and its relationship with XIAP expression in breast cancer tissues.Method The expression of p62 and XIAP was detected by immunohistochemistry of EnVision two-step in 94 cases of breast carcinoma before and after NCT.The changes of p62 and XIAP expression after NCT were observed and their correlation was also analyzed.Results High expression rate of p62 and XIAP was 51.1％ (48/94)and 84.0％ (79/94) respectively in breast cancer tissues before NCT.The high expression rate of p62 was increased to 81.9％ (77/94) and that of XIAP was reduced to 35.1％ (33/94) in breast cancer tissues after NCT.The high expression rate of p62 was significantly increased while that of XIAP was significantly decreased after NCT (P both ＜ 0.05).The sample rate of increased expression of p62 and decreased expression of XIAP was 73.4％ and 75.5％ after NCT respectively.Furthermore,the change of p62 expression was significantly negatively correlated with the change of XIAP (P ＜ 0.01).Conclusion Suppression of XIAP and increased autophagic activity coexist in breast cancer after NCT,and XIAP may be involved in the negative regulation of enhanced autophagy.
