Fabrication and in vitro biological safety of a novel functional coating on microarc-oxidized titanium
10.3969/j.issn.1001-3733.2017.02.004
- VernacularTitle:新型钛种植体涂层构建及体外生物安全性评价
- Author:
Rui MA
;
Peng SHEN
;
Yifan LIU
;
Bo GAO
;
Jiang WU
- Keywords:
Titanium implant;
Drug-loaded Nanospheres;
Coating;
Biological safety
- From:
Journal of Practical Stomatology
2017;33(2):157-161
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To fabricate and to study the surface morphology and biological safety of a novel coating on microarc-oxidized titanium.Methods:The novel functional coating was fabricated by cross-linking the double-layer nanoparticles loading rhBMP-2 and SDF-1 with gelatin on microarc-oxidation coating on titanium implant surface.The surface topography was observed and optimized,and the biological safety of the novel coating was primarily evaluated by cell toxicity test,oral mucosa stimulation test and hemolysis test in vitro.Results:The novel functional coating possesses excellent morphology.The coating showed the cytotoxicity of score 1 and no mucous membrane irritation,the hemolytic rate of the coating was 4.6％.Conclusion:The coating possesses good morphology and biological safety.
