The relationship of LncRNA H19 with the occurrence and the carcinogenesis of OSF
10.3969/j.issn.1001-3733.2017.02.020
- VernacularTitle:LncRNA H19与OSF发生及癌变的关系
- Author:
Hua SU
;
Shenyue ZHOU
;
Xincheng GUO
;
Haiqing WANG
;
Cui LI
;
Jianhua HUANG
- Keywords:
Oral submucous fibrosis(OSF);
Carcinogenesis;
LncRNA H19
- From:
Journal of Practical Stomatology
2017;33(2):235-238
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the significance of H19 gene in the progress from normal mucosa through oral submucous fibrosis (OSF) to carcinogenesis.Methods:Real-time fluorescent quantitative PCR technique was used to detect LncRNA H19 expression level in 12 cases of normal buccal mucosa tissue,33 cases of OSF buccal mucosa tissue and 31 cases of buccal carcinoma with OSF.Results:The relative expression levels of LncRNA H19 in normal buccal mucosa tissues,OSF buccal mucosa tissue and buccal carcinoma with OSF tissue were 1.17 ±0.37,3.44 ± 1.08 and 8.88 ± 1.78 respectively(between each 2 groups,P ＜ 0.01).Conclusion:H19 may involve the occurrence and canceration of OSF.
