The expression and significance of IGFBP-3 in salivary gland pleomorphic adenoma
10.3969/j.issn.1001-3733.2017.02.025
- VernacularTitle:IGFBP-3在唾液腺多形性腺瘤中的表达及意义
- Author:
Hang XIANG
;
Hong MA
;
Xiaofeng DUAN
- Keywords:
Insulin-like growth factor binding protein 3 (IGFBP-3);
Salivary pleomorphic adenoma (SPA);
Western blot;
Real-time PCR
- From:
Journal of Practical Stomatology
2017;33(2):258-261
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of insulin-like growth factor binding protein 3 (IGFBP-3) in salivary pleomorphic adenoma(SPA).Methods:The expression of IGFBP-3 protein in 40 cases of SPA(group SPA),40 of normal glandular tissue(group N) and 10 of salivary gland malignant tumor(group CA) was detected by Western blot.The expression of IGFBP-3 mRNA in 50 cases of SPA,50 of salivary gland normal tissue and 10 of CA was detected by qRT-PCR.Results:The expression(A value) of IGFBP-3 protein in group N,SPA and CA was 8.54 ± 3.95,4.78 ± 2.07,3.63 ± 2.27 respectively.The expression ration of IGFBP-3 mRNA of group N vs SPA or CA,P ＜ 0.05;SPA vs CA,P ＞ 0.05 (SPA/N was 0.654 ± 0.387,CA/N:0.452 ± 0.229) respectively,but showed no significance difference between SPA and the CA groups(P ＞ 0.05).Difference of IGFBP-3 mRNA expression was observed with different envelope infiltration of SPA (P ＜ 0.05),no significant difference was observed in different age,gender or relapse groups.Conclusion:IGFBP-3 Low expression of IGFBP-3 in pleomorphic adenomas may reduce the antagonism of IGF-1R,causing the proliferation of tumor cells and promote tumor formation.
