Diagnostic value of BG and GM test for invasive fungal infections in ICU patients

VernacularTitle:1,3-β-D葡聚糖和半乳甘露聚糖检测对ICU患者侵袭性真菌感染的诊断价值
Author: Tingting SUN ; Yi WANG
Keywords: intensive care unit; 1; 3-β-D glucan; galactomannan; invasive fungal infections
From: International Journal of Laboratory Medicine 2017;38(11):1468-1470
CountryChina
Language:Chinese
Abstract: Objective To evaluate the early diagnostic value of 1,3-β-D glucan(BG) and galactomannan(GM) test for invasive fungal infections(IFI)in intensive care unit(ICU) patients.Methods From 2013 to 2015,the concentration of serum BG and GM were detected in 452 cases of ICU patients,including 182 cases with diagnosis of IFI,46 cases with possible diagnosis of IFI and 224 cases of non-IFI.The diagnostic performance of BG,GM and combined test were analyzed.Results The sensitivity,specificity,positive predictive value(PPV) and negative predictive value(NPV)of BG test were 75.0%,80.4%,75.8%,79.6%.Those of GM test were 25.80%,85.7%,59.5% and 58.7%.The sensitivity and specificity of BG and GM combined test were 87.4% and 94.7% respectively.Conclusion BG and GM combined test could improve the diagnostic efficiency,reduce the false positive rate and false negative rete,which might be helpful for the early diagnosis of IFI in ICU patients.