Regional homogeneity of resting-state brain activity in knee osteoarthritis patients with chronic pain
10.11659/jjssx.12E016064
- VernacularTitle:膝骨性关节炎患者慢性疼痛静息态脑功能局部一致性研究
- Author:
Aijun SHI
;
Chunlei LI
;
Yuan WU
;
Kaihang JIANG
;
Xingtao HUANG
;
Tian LUO
;
Jing WANG
- Keywords:
knee osteoarthritis;
chronic pain;
functional magnetic resonance;
resting-state;
regional homogeneity
- From:
Journal of Regional Anatomy and Operative Surgery
2017;26(6):419-422
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of resting-state brain activity in knee osteoarthritis(KOA)patients with chronic pain.Methods The data of 21 KOA patients (KOA group) and 21 healthy controls (HC group) who underwent standard resting-state fMRI scan were analyzed with regional homogeneity (ReHo) method to observe the changes in the patients in contrast to the controls.Results Compared to HC group,patients of the KOA group showed ReHo changes in bilateral frontal lobe,bilateral parietal lobe,bilateral temporal lobe,bilateral cerebellum,limbic system and default-mode network.Conclusion Patients with chronic pain demonstrate abnormal neuron activities in the brain regions, and control loops not only related with pain but also related with emotive function disorder and cognitive impairment.
