Correlation between serum lipid level and carotid artery stenosis in patients with ischemic cerebrovascular disease:a multi-center registry study
10.3969/j.issn.1672-5921.2017.06.003
- VernacularTitle:血脂水平与缺血性脑血管病患者颈动脉狭窄关系的多中心登记研究
- Author:
Yunlu TAO
;
Yang HUA
;
Lingyun JIA
;
Yingqi XING
;
Pinjing HUI
;
Xuan MENG
;
Delin YU
;
Xiaofang PAN
;
Yalan FANG
;
Binbin SONG
;
Chunxia WU
;
Chunmei ZHANG
;
Xiufang SUI
;
Youhe JIN
;
Jingfen ZHANG
;
Jianwei LI
;
Ling WANG
;
Yuming MU
;
Jingxin ZHONG
;
Yuhong ZHU
;
Heng ZHANG
;
Xiaoyu CAI
- Keywords:
Carotid stenosis;
Arteriosclerosis;
occlusive;
Dyslipidemias;
Cholesterol;
low density lipoprotein;
Cholesterol
- From:
Chinese Journal of Cerebrovascular Diseases
2017;14(6):292-296
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of serum lipid level on carotid artery stenosis in patients with ischemic cerebrovascular disease.Methods Using a multi-center cross-sectional study,10 711 consecutive inpatients with transient ischemic attack (TIA) or ischemic stroke diagnosed clearly in 20 stroke screening and prevention project base hospitals from June 2015 to May 2016 were enrolled.According to the results of carotid ultrasonography,1 560 patients with extracranial carotid artery stenosis rate≥50% screened were enrolled in the study.They were divided into a severe stenosis group (70%-99%) and a mild-moderate stenosis group (<70%).The distribution of total cholesterol (TC),triacylglycerol (TG),low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) levels in both groups of carotid stenosis patients were analyzed,and the quantitative classification was based on the normal range of serum lipids.The distributions of serum lipid levels in different grades in patients of both groups were compared with the non-parameter test.Results The incidence of dyslipidemia in the severe stenosis group was higher than that in the mild and moderate stenosis group.There was no significant difference between the two groups (54.4%[319/586]vs.48.3%[470/974],P<0.05).Dyslipidemia was an independent risk factor for severe carotid artery stenosis (OR,1.27,95% CI 1.24-1.30,P<0.01).The TC and LDL-C levels in patients of the severe stenosis group were significantly higher than those in the mild-moderate stenosis group (TC:3.98[3.31,4.82]mmol/L vs.3.91[3.31,4.53]mmol/L,LDL-C:2.48[1.86,3.14]vs.2.30[1.79,2.80];all P<0.01).With the increase of TC and LDL-C levels,there was significant differences between the severe stenosis group and the mild-moderate stenosis group (all P<0.05),and the proportions of TC >5.80 mmol/L (7.3%[43/586]vs.0.4%[4/974]) and LDL-C>3.12 mmol/L (26.3%[154/586]vs.10.0%[97/974]) in patients of the severe stenosis group were higher than those in the mild-moderate stenosis group (26.3%[154/586]vs.10.0%[97/974]).Conclusion The high LDL-C and TC levels may increase the incidence of severe carotid artery stenosis or occlusion.
