Correlation between smoking and occurrence of intracranial artery stenosis by ultrasonography:an analysis of multi-center research results
10.3969/j.issn.1672-5921.2017.06.004
- VernacularTitle:超声检测吸烟与颅内动脉狭窄相关性的多中心研究结果分析
- Author:
Ran LIU
;
Yang HUA
;
Lingyun JIA
;
Yingqi XING
;
Pinjing HUI
;
Xuan MENG
;
Delin YU
;
Xiaofang PAN
;
Yalan FANG
;
Binbin SONG
;
Chunxia WU
;
Chunmei ZHANG
;
Xiufang SUI
;
Youhe JIN
;
Jingfen ZHANG
;
Jianwei LI
;
Ling WANG
;
Yuming MU
;
Jingxin ZHONG
;
Yuhong ZHU
;
Heng ZHANG
;
Xiaoyu CAI
- Keywords:
Cerebrovascular disease;
Intracranial artery stenosis;
Smoking;
Transcranial Doppler sonography
- From:
Chinese Journal of Cerebrovascular Diseases
2017;14(6):297-301,312
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between smoking and occurrence of intracranial artery stenosis.Methods From June 2015 to May 2016,a total of 10 711 inpatients with transient ischemic attack (TIA) or ischemic stroke from 20 basel hospitals of nationwide were enrolled using a cross-sectional study,76 patients with unknown smoking and smoking cessation years were excluded.Finally,a total of 10 635 patients were enrolled.Transcranial color coded sonography and/or transcranial Doppler were used evaluate the intracranial artery stenosis lesions.The basic risk factors for cerebrovascular disease (age,sex,smoking and smoking years,whether smoking cessation and years,hypertension,diabetes,hyperlipidemia,atrial fibrillation,and family history of stroke) were recorded.According to the different smoking years,the smoking years were divided into five groups:non-smoking,smoking time ≤10-year,11 to 20-year,21 to 30-year,and >30-year groups for trend chi square test.According to the different smoking cessation years in the smokers,the smoking cessation years were divided into four groups:non-cessation,cessation time 1 to 10-year,11 to 20-year,and >20-year groups for trend chi square test.The effects of different smoking years and different smoking cessation years on the occurrence of intracranial arterial stenosis were analyzed.Results The incidence of intracranial artery stenosis in the smokers (40.4%[1 433/3 547]) was significantly higher than that in the non-smoking patients (29.4%[2 085/7 088]).There was significant difference (χ2=128.850,P<0.01),and the incidence of cerebral infarction in the smokers (91.6%[3 250/3 547]) was significantly higher than the non-smokers (85.0%[6 027/7 088]).There was significant difference (χ2=92.328,P<0.01).Smoking was an independent risk factor for intracranial artery stenosis (OR,1.603;95%CI 1.456-1.765;P<0.01).With the increase of smoking years,the detection rate of intracranial arterial stenosis increased gradually (trend χ2=115.437,P<0.01).Whether giving up smoking had no significant effect on the incidence of intracranial artery stenosis in patients with ≥20 years of smoking (trend χ2=1.043,P=0.307).Conclusions Smoking is an independent risk factor for affecting intracranial artery stenosis;the risk of disease increases with the number of smoking years.Long-term smokers (≥20 years) cannot reduce the effect on intracranial artery stenosis,even if they give up smoking.
