Expression of Ki67 and clinical significance in breast cancer
10.3969/j.issn.1673-4130.2017.11.009
- VernacularTitle:Ki67在乳腺癌组织中的表达及其临床意义研究
- Author:
Lin YUAN
;
Wenhui ZHOU
;
Weiwei ZHAO
;
You PENG
;
Xiufen LIU
;
Jing FENG
- Keywords:
breast cancer;
Ki67;
immunohistochemistry;
prognosis
- From:
International Journal of Laboratory Medicine
2017;38(11):1464-1467
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression level of Ki67 and its correlation with clinicopathological types and prognosis of patients with breast cancer.Methods Clinical data of 93 patients with breast cancer and 20 patients with benign breast diseases were collected from Jan.2013 to Dec.2015,and the correlation between Ki67 and pathological parameters and laboratory parameters were analyzed.Results Among the 93 patients with breast cancer,the Ki67 index was 1% to 90%,with median of 21.65%.Ki67 index was correlated with tumor grade,tumor size and human epidermalgrowth factor receptor-2(HER2,P<0.05).However,Ki67 index was without correlation with age,menopausal status,tumor TNM stage,lymph node metastasis,estrogen receptor(ER) and progesterone receptor(PR,P>0.05).Ki67 index of patients with triple negative breast cancer,patients with non-triple negative breast cancer and patients with benign breast diseases were 30.15%,20.26% and 4.67%,which were with significant difference(P<0.04).Ki67 index was also related to the breast cancer subtypes(P<0.05),and serum potassium and hematocrit levels of patients with breast cancer(P<0.05).Conclusion Ki67 index could be used for the diagnosis,treatment and prognosis of patients with breast cancer.
