Effect of OXC and VPA on EEG,Hcy and ADMA in adult patients with partial epilepsy
10.3969/j.issn.1673-4130.2017.11.013
- VernacularTitle:奥卡西平和丙戊酸钠对成人部分性癫痫患者脑电图及相关血液学指标水平的影响
- Author:
Miao TIAN
;
Li ZHANG
;
Yu XU
;
Yalin FAN
- Keywords:
oxcarbazepine;
sodium valproate;
partial epilepsy;
electroencephalogram;
homocysteine;
asymmetric dimethylarginine
- From:
International Journal of Laboratory Medicine
2017;38(11):1477-1479
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of oxcarbazepine(OXC) and sodium valproate(VPA) on electroencephalogram(EEG) and peripheral blood levels of homocysteine(Hcy) and asymmetric dimethylarginine(ADMA) in adult patients with partial epilepsy.Methods From May.2014 to May.2015,a total of 100 patients with partial epilepsy were enrolled and randomly divided into treatment group(treated with OXC) and control group(treated with VPA),with 50 cases in each group.After treatment,changes of EEG indices,Hcy,ADMA,cognitive function and adverse reaction were analyzed.Results Before treatment,there was no significant difference of EEG indices between the two groups(P>0.05).After treatment,the incidence rates of α wave decreasing more than 0.5 Hz,increasing of θ wave and increasing of δ wave were significantly different(P< 0.05).Before treatment,there was no significant difference of serum Hcy and ADMA levels between the two groups(P>0.05).After treatment,serum Hcy and ADMA levels were both significantly increased(P<0.05).Before treatment,Mini-mental State Examination(MMSE) scores of the two groups were without significant difference(P>0.05).After treatment,MMSE score of treatment group was higher than that of control group(P<0.05).In treatment group,there were 1 case of skin rash and 2 cases of gastrointestinal discomfort,which were self-improved.In control group,there were 3 cases of dizziness,5 cases of skin rash and 1 case of gastrointestinal discomfort,which were self-improved.Conclusion The effects of OXC and VAP on peripheral blood levels of Hcy and ADMA could be similar,and compared with VAP,OXC could significantly improve cognitive function in patients with epilepsy.
