The effect of Polygonatum Sibiricum Polysaccharide on the expression of OPG and RANKL in the rat model of ovariectomy-induced osteoporosis

VernacularTitle:黄精多糖对去卵巢大鼠骨质疏松模型中OPG和RANKL蛋白表达的影响
Author: Fangna YAN ; Gaofeng ZENG ; Shaohui ZONG ; Xiaoming PENG ; Pingping WU ; Lei ZHANG ; Jichen HE ; Chengming WEI ; Xiongzhi SHI
Keywords: PSP; Osteoporosis; OPG,RANKL
From: The Journal of Practical Medicine 2017;33(8):1243-1246
CountryChina
Language:Chinese
Abstract: Objective To investigate PSP on bone microstructures,Ca,P,OPG and RANKL of osteoporotic rat model.Methods Thirty female rats randomly divided into five groups:Sham,OVX,H-,M-,L-PSP.Sham and OVX were irrigated stomachsaline;PSP solution was gavaged to other groups.After 8-week,bone microstructures of tibial metaphyseal,Ca,P,OPG and RANKL were measured.Results Body weight,Ca,P,RANKL,Tb.Sp of OVX were significantly increased compared to Sham,OPG,BV/TV,Tb.Th,Tb.N decreased.Body weight of H-,M-PSP,Ca and Tb.Sp of PSP,P and RANKL in H-PSP were decreased compared to OVX,OPG in H-,M-PSP,BV/TV,Tb.Th,Tb.N of PSP group increased.The differences were statistically significant (P ＜ 0.05).Conclusion PSP prevents osteoporosis by improving the microstructure of trabecular bone,reducing bone turnover,increasing OPG and reducing RANKL expression.