Detection of the retina degeneration in the early stage of Alzheimer's disease by spectral domain optical coherence tomography

VernacularTitle:频域OCT技术用于早期检测阿尔兹海默症患者黄斑区视网膜厚度改变的研究
Author: Xiangjun DAI ; Changzheng CHEN
Keywords: OCT; Alzheimer's disease; Retina
From: The Journal of Practical Medicine 2017;33(8):1277-1280
CountryChina
Language:Chinese
Abstract: Objective To evaluate the applicability and reliability of optical coherence tomography (OCT) technical in detecting the thickness changes of ganglion cell complex (GCC) and outer retinal layers (ORL) in Alzheimer's disease.Method 28 AD patients and 30 healthy control subjects were recruited.SD-OCT was used to measure the macular ganglion cell complex thickness and outer retinal thickness.Cognitive function was evaluated by Mini-Mental State examination (MMSE).Intra-ocular tension and axis length were measured at the same time.Results OCT data shows statistic difference of ganglion cell complex thickness between AD group and control group,while there is no significant difference of outer retinal layers thickness between the two groups.Significant correlations between GCC thickness and MMSE scores were observed.There was no significant correlation between the MMSE scores and the ocular tension.Conclusions Retinal thickness reduction of AD patients can be detected by OTC,and could be related with disease progression.OCT can be used to screen the early stage AD patient.