Regulative effect of Xuanbai Chengqi Decoction on TNF-α and IL-1β in patients with acute respiratory distress syndrome and its mechanical indexes
10.3969/j.issn.1006-5725.2017.08.038
- VernacularTitle:宣白承气汤对急性呼吸窘迫综合征患者炎性因子TNF-α、 IL-1β调控及力学指标研究
- Author:
Bo FENG
;
Zhengrong MAO
;
Yang DENG
- Keywords:
Acute respiratory distress syndrome;
Xuanbaichengqi decoction;
Respiratory mechanics;
Inflammatory factors
- From:
The Journal of Practical Medicine
2017;33(8):1337-1340
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of Xuanbaichengqi decoction on the regulation of inflammatory factors TNF-α and IL-1 β in patients with acute respiratory distress syndrome (ARDS) and its mechanism.Methods 60 patients with ARDS who had been hospitalized from January 2016 to August 2016 were randonly selected and then assigned to a control group (30 patients) and a study group (30 patients).Both groups received routine therapies and mechanical ventilation,and the study group received additional Xuanbaichengqi decoction.Levels of TNF-o,IL-1β and IL-10,and peak inspiratory pressure (PIP),plateau airway pressure (Pplat),PVC,forced vital capacity (FVC),forced expiratory volume in one second (FEV 1),and oxygenation index (PaO2/FiO2) were detected before and after treatment.Results Levels of TNF-α and IL-1βwere significantly lower in the study group than in the control group (P ＜ 0.05).IL-10 level was significantly higher in the study group than in the control group (P ＜ 0.05).And the improvement in PIP and Pplat was also significant in the study group (P ＜ 0.05).Less adverse reactions occurred in the study group.Conclusions Xuanbaichengqi decoction can improve the indexes for respiratory mechanics and pulmonary function in patients on mechanical ventilation and reduce the inflammatory response,having a significant effect.
