Determination and significance of monocyte chemotactic protein-3 and microvessel density in muscular tissue of patients with dermatomyosits and polymyosits
10.3969/j.issn.1006-5725.2017.07.025
- VernacularTitle:单核细胞趋化蛋白3及微血管密度在皮肌炎和多发性肌炎患者肌肉组织中的测定及意义
- Author:
Lingshuang KONG
;
Kexia CHAI
;
Yuqi CHEN
- Keywords:
Dermatomyosits;
Polymyosits;
Monocyte chemotactic protein-3;
CD34,Microvessel density
- From:
The Journal of Practical Medicine
2017;33(7):1113-1116
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the levels of monocyte chemotactic protein-3(MCP-3) and microvessel density (MVD) labeled by CD34 in skeletal muscle of patients with dermatomyositis (DM) and polymyositis (PM),so as to investigate the pathogenesis of DM/PM.Methods The expression of MCP-3 and MVD were detected in DM/PM patients and the healthy controls by using the immunohistochemical method.Results The positive expression rate of MCP-3 in DM group and PM group were higher than that in the control group (P ＜ 0.001,respectively).The microvessel marked by CD34 could be observed in muscle tissue of patients in DM group and PM group,and MVD in DM group and PM group was higher than that in the control group (P ＜ 0.001).No significant differences in the level of MCP-3 and MVD in the muscle tissue were found between the DM group and the PM group.The positive correlation between MCP-3 protein expression and MVD changes in the muscle tissue of patients inDM group and PM group was revealed (r =0.685/0.634,P ＜ 0.05).Conclusion The muscle tissue of DM/PM patients may have a new blood vessel formation,MCP-3 may be involved the process of new blood vessel formation in DM/PM.
