Expression and clinical implications of Wnt-1 and FZD-1 in small cell lung cancer patients
10.3969/j.issn.1006-5725.2017.07.035
- VernacularTitle:Wnt-1和FZD-1在小细胞肺癌患者中的表达及临床意义
- Author:
Lixia LI
;
Wenmei SU
;
Yalian YUAN
;
Min CHEN
;
Quanchao LV
;
Dong WU
- Keywords:
Small cell lung cancer;
Wnt-1;
FZD-1;
Chemotherapy resistance;
Clinical feature;
Prognosis
- From:
The Journal of Practical Medicine
2017;33(7):1149-1152
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of Wnt-1 and FZD-1 in small cell lung cancer(SCLC) patients and their relations with chemotherapy resistance,clinical feature and prognosis.Methods Peripheral blood specimens were collected from 41 SCLC patients.The expression of Wnt-1 and FZD-1 in peripheral blood monouclear cells (PBMC) were detected.The relationship among the expression of Wnt-1 and FZD-1,clinicopathologic feature and prognosis was analyzed.Results The relative expression of Wnt-1 and FZD-1 in chemotherapy resistant group was significantly higher than that in chemotherapy sensitive group (all P ＜ 0.05).The expression of Wnt-1was positively correlated with that of FZD-1 (r =0.186,P ＜ 0.05).The FZD-1expression level was not correlated with patients' age,sex and smoking history (all P ＞ 0.05),but closely with clinic-staging (P =0.008).The Wnt-1 expression level was not correlated with patients' clinical features (all P ＞ 0.05).There was statistical difference in median survival time between Wnt-1 and FZD-1 high-expression group and low-expression group.Conclusions Wnt-1 and FZD-1relationships with chemotherapy resistance and prognosis.Wnt-1 and FZD-1 may act as an important role in chemotherapy resistance of SCLC and could be served as indicators for the chemotherapy resistance and outcome assessment of SCLC.
