Study on Compatible Stability of Voriconazole for Injection Combined with 2 Kinds of Injections
10.6039/j.issn.1001-0408.2017.17.11
- VernacularTitle:注射用伏立康唑与2种注射液的配伍稳定性研究
- Author:
Xiaohong CUI
;
Jinmin REN
;
Meng LIU
;
Zekun KANG
;
Ying GONG
- Keywords:
Compatibility stability;
Voriconazole for injection;
Fructose injection;
Invert sugar injection;
HPLC
- From:
China Pharmacy
2017;28(17):2343-2346
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the compatible stability of Voriconazole for injection after mixed with Fructose injec-tion or Invert sugar injection. METHODS:Referring to package inserts,Voriconazole for injection 200 mg was dissolved with Wa-ter for injection to 20 mL,and then combined with Fructose injection 250 mL and Invert sugar injection 250 mL,respectively. At room temperature,the appearance of mixtures were observed 0,1,2,3,4,5 h after mixing,and pH value and the number of in-soluble particles were determined;the content of voriconazole was determined by HPLC. RESULTS:Under above condition,the appearance and pH value of mixtures had no significant change within 5 h;the number of particles ≥10 μm and ≥25 μm were all in line with the standard of Chinese Pharmacopoeia (2015 edition);the relative content of voriconazole was decreasing (95.28%-100%),but it changed within ±5%(RSD<2%,n=6). CONCLUSIONS:Voriconazole for injection could keep stable within 5 h after mixed with Fructose injection or Invert sugar injection.
