Clinical Observation of Argatroban in the Treatment of Progressive Stroke of Different Ischemic Ranges
10.6039/j.issn.1001-0408.2017.17.24
- VernacularTitle:阿加曲班治疗不同脑组织缺血范围进展性脑卒中的临床观察
- Author:
Yong FENG
;
Xuechao YU
;
Hongyuan MENG
;
Tonghua ZHANG
- Keywords:
Anterior circulation ischemics stroke;
Posterior circulation ischemics stroke;
Lacunar cerebral infarction;
Argatroban
- From:
China Pharmacy
2017;28(17):2392-2395
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study clinical effect of argatroban for progressive stroke patients of different cerebral ischemic ranges. METHODS:A total of 116 progressive stroke patients selected from neurology department of our hospital during Feb. 2015-May 2016 were divided into anterior circulation (ischemia) group (n=60),posterior circulation (ischemia) group (n=50) and lacunar(cerebral infarction)group(n=6)according to cerebral ischemic ranges. They all received routine treatment combined with argatroban,and given continuous intravenous infusion of argatroban 60 mg/d on the day and 2nd day of disease aggravation, and then continuous intravenous infusion of argatroban 5th day after relieving,3 h/time,bid,7 d as a treatment course. NIHSS scores,modified RANKIN (mRS) scores,APTT and ADR were compared among 3 groups. RESULTS:Forteen days after treat-ment,NIHSS scores and mRS scores of 3 groups were decreased significantly compared to before treatment,with statistical signifi-cance (P<0.05). There was statistical significance between anterior circulation group and posterior circulation group (P<0.05). Two hours after treatment,APTT of 3 groups were prolonged significantly,especially in lacunar group,with statistical significance (P<0.05). Forty hours after treatment,APTT of 3 groups were recover to normal,without statistical significance (P>0.05). No obvious ADR was found in 3 groups. CONCLUSIONS:Argatroban shows significant therapeutic efficacy for progressive stroke of different ischemic ranges with good safety;especially for the patients with anterior circulation ischemics stroke,the effect is quick and anticoagulant effect is significant.
