The clinical manifestation and gene mutation of primary renal glucosuria in a child

VernacularTitle:儿童原发性肾性糖尿1例临床及基因突变分析
Author: Qun LI ; Guoying CHANG ; Yu DING ; Juan LI ; Qing CHENG ; Xin LI ; Jian WANG ; Xiumin WANG ; Yiping SHEN
Keywords: primary renal glucosuria; SLC5A2 gene; SGLT2 protain; gene mutation
From: Journal of Clinical Pediatrics 2017;35(6):418-420
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical manifestation and gene mutation of primary renal glucosuria (PRG). Methods The clinical data and gene detection results of a child with PRG were analyzed. Results A girl aged 2 years and 10 mouths had glucose ++++ by urine dipstick analysis and 22.4 g of the 24 h urine glucose. Her father was urine glucose positive. Genome DNA was extracted from peripheral blood of the girl and her parents, SLC5A2 gene were amplified by PCR for sequencing, including exons and splicing areas. The results showed a homozygous point mutation (c.127-16C>A) in girl, and both of her patents had the same heterozygous mutation. This mutation had been classified to pathogenic mutations by ClinVar data base. Conclusions The diagnosis of PRG is confirmed in this child and SLC5A2 gene mutation is the cause.