The risk factors of severe birth defects and mild birth defects of Guangdong province
10.3760/cma.j.issn.1008-6706.2017.13.031
- VernacularTitle:广东省佛山市顺德区胎婴儿严重出生缺陷和轻微出生缺陷相关危险因素的比较研究
- Author:
Yanling HUANG
;
Shanshan SONG
- Keywords:
Birth defects;
Risk factors;
Case-control study
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(13):2043-2047
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find out and compare the risk factors of the severe birth defects and mild birth defects,and make it more effective to prevent the severe birth defects.Methods Fetus diagnosed with severe birth defects in Shunde district,Foshan during 2016 were selected as case group 1,those who diagnosed with moderate/mild birth defects were selected as case group 2,and those healthy infants whose mother's last menstrual period was at the same time with the case groups were selected as control group.Their mothers' relative information was collected.A case-control study was conducted to analyze the risk factors of the two case groups respectively.We applied Chi-square analysis and multivariate Logistic regressions to find out the independent risk factors.Results Chi-square analysis showed that maternal age above 35 years(χ2=19.69,P<0.01) and gravidity 3 times or more(χ2=10.06,P<0.01) were the risk factors of severe birth defects,and twins was the risk factor of mild birth defects(χ2=4.05,P<0.05).The multivariate Logistic regressions showed that maternal age above 35 years was the independent risk factor of severe birth defects(OR=2.75,P<0.001),and twins was the independent risk factor of mild birth defects(OR=2.22,P=0.05).Conclusion The women with age above 35 years have higher risk to pregnant a baby with severe birth defects and they are worthy of more attention during pre-pregnancy and antenatal examinations.
