Relationship Between Endogenous Estrogen Level and Myocardial No-reflow After Reperfusion in Postmenopausal Acute ST-elevation Myocardial Infarction Patients
10.3969/j.issn.1000-3614.2017.06.006
- VernacularTitle:绝经后内源性雌激素水平与急性ST段抬高型心肌梗死患者心肌再灌注后无复流的关系
- Author:
Haiqiu DONG
;
Mei DONG
;
Faxin REN
- Keywords:
Myocardial infarction;
Estrogens;
No-reflow
- From:
Chinese Circulation Journal
2017;32(6):552-555
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the relationship between endogenous estrogen level and myocardial no-reflow after reperfusion in postmenopausal acute ST-elevation myocardial infarction (STEMI) patients. Methods: A total of 100 postmenopausal STEMI patients with percutaneous coronary intervention (PCI) were enrolled and divided into 2 groups: Reflow group,n=77 and No-reflow group,n=23. Myocardial no-reflow was defined by TIMI≤2 grade or TIMI 3 grade and MBG≤2 grade after PCI. Blood levels of endogenous estrogen were examined before PCI; the relationship between endogenous estrogen level and myocardial no-reflow was assessed by Logistic regression analysis. Results: Compared with Reflow group, No-reflow group showed increased blood levels of estrone, estradiol, high sensitivity C-reaction protein (hs-CRP),P<0.05 and decreased sex hormone binding globulin (SHBG),P<0.05. Univariate analysis indicated that the length of lesion, thrombus score≥4, blood levels of estrone, estradiol and hs-CRP were positively related to no-reflow occurrence,P<0.05. Multi Logistic regression analysis presented that thrombus score≥4 (OR=4.994, 95%CI 1.987-10.518,P=0.035) and estradiol level (OR=4.091, 95% CI 1.105-8.582;P=0.046) were the independent risk factors for no-reflow occurrence. Conclusion: High blood level of endogenous estrogen was positively related to myocardial no-reflow after PCI in postmenopausal STEMI patients, which implied that endogenous estrogen might be the independent risk factor for no-reflow occurrence.
