The research progress of extracellularvesicles for drug delivery as natural nanocarriers
10.3969/j.issn.1001-1978.2017.06.005
- VernacularTitle:胞外囊泡作为药物传递天然纳米载体的研究进展
- Author:
Huanyan ZHANG
;
Xuefeng WANG
;
Yongbin MA
;
Li LI
;
Yang SHU
;
Yi WANG
- Keywords:
extracellular vesicles;
drug delivery;
natural nanocarriers;
immunotherapy;
clinical trial;
research progress
- From:
Chinese Pharmacological Bulletin
2017;33(6):757-760
- CountryChina
- Language:Chinese
-
Abstract:
Phospholipid membrane vesicles from cells play key roles in cell communication, antigen presentation, and transmission of infectious agents.Extracellular vesicles(EVs) carry various proteins, mRNA, and microRNA(miRNA), like a truck to bring different molecular cargoes to remote cells.Furthermore, the encapsulated molecules by EVs can be prevented from being degraded by enzymes in body fluids, making EVs as a natural, novel drug delivery system.In this paper, we review the progress of EVs for biological application and drug delivery vehicles from the classification and composition, which provides a theoretical basis for seeking new drug delivery systems for the treatment of diseases.
