Correlation Study Between Serum Platelet Derived Growth Factor Level and Ultrasound Imaging Features of Coronary Atherosclerotic Plaques in Relevant Patients
10.3969/j.issn.1000-3614.2017.06.008
- VernacularTitle:血清血小板源性生长因子与冠状动脉粥样硬化斑块超声显像特征的关系研究
- Author:
Caihong YU
- Keywords:
Coronary artery disease;
Platelet derived growth factor;
Echocardiography
- From:
Chinese Circulation Journal
2017;32(6):560-563
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To detect the features of atherosclerotic plaques and their correlation to serum platelet derived growth factor (PDGF) level in patients with different types of coronary artery disease (CAD) by intravascular ultrasound (IVUS). Methods: A total of 106 patients admitted in our hospital with coronary angiography from 2011-01 to 2013-10 were enrolled and divided into 2 groups: Acute coronary syndrome (ACS) group,n=60 and Stable angina pectoris (SAP) group, n=46. Basic information as gender, age, history of smoking, hypertension and diabetes were recorded in all patients; serum levels of PDGF were measured by ELISA. IVUS was conducted to examine coronary atherosclerotic plaque morphology, property, rupture, thrombosis and refactoring in criminal vessels; meanwhile, external elastic membrane area, lumen area, plaque area and eccentric index were determined at the lesion site. The above parameters were compared between 2 groups and the correlation of different types of plaques to serum levels of PDGF were studied. Results:①Serum PDGF level in SAP group was higher than ACS group (3.64±0.60) ng/L vs (2.12±0.51) ng/L,P<0.05.②The patients in SPA group were mainly having hard plaque and in ACS group were mainly having soft plaque. Compared with SAP group, ACS group had the higher incidences of plaque rupture, thrombosis and positive refactoring; ACS group was mainly with eccentric plaque with low eccentric index allP<0.05-0.01; ACS group had the larger external elastic membrane area at the lesion site,P<0.05.③The patients with fibrous plaque, calcified plaque and mixed plaque (hard plaque) had the lower serum levels of PDGF than those with soft plaque,P<0.05. Conclusion: PDGF had been involved in atherosclerotic plaque formation and it played an important role in ACS pathogenesis. The patients with unstable plaques had the higher serum PDGF level, therefore PDGF detection may help ACS diagnosis and prediction.
