Current status of research on prediction of radiotherapy induced adverse reactions by radiation genomics
10.3760/cma.j.issn.1004-4221.2017.06.024
- VernacularTitle:放射基因组学与放疗不良反应预测的研究现状
- Author:
Lipin LIU
;
Nan BI
;
Lyuhua WANG
- Keywords:
Radiation Genomics;
Neoplasms/radiotherapy;
Adverse reactions
- From:
Chinese Journal of Radiation Oncology
2017;26(6):711-714
- CountryChina
- Language:Chinese
-
Abstract:
The occurrence and severity of radiotherapy-induced adverse events cannot be accounted for or predicted by therapeutic and clinical factors alone.Evidence suggests that genetic variants are associated with adverse effects following radiotherapy.Radiation genomics is the study of genetic variants associated with radiotherapy toxicity.Radiation genomics aims to develop a risk prediction model and uncover the biological mechanisms responsible for radiotherapy toxicity.With the advances in genomics and bioinformatics in the past two decades,radiation genomics has evolved from candidate gene studies to genome-wide association studies,with a series of progress.In this review,we will discuss the study background,design,approaches,challenges,and future directions for radiation genomics.
