A prospective control study of Saccharomyces boulardii in prevention of antibiotic-associated diarrhea in the older inpatients
10.3760/cma.j.issn.0578-1426.2017.06.003
- VernacularTitle:布拉酵母菌预防住院老年患者抗生素相关性腹泻的前瞻性随机对照研究
- Author:
Dongmei ZHANG
;
Binbin XU
;
Li YU
;
Linfu ZHENG
;
Longping CHEN
;
Wen WANG
- Keywords:
Aged;
Antibiotic-associated diarrhea;
Prevention;
Saccharomyces boulardii
- From:
Chinese Journal of Internal Medicine
2017;56(6):398-401
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the value of Saccharomyces boulardii for the prevention of antibiotic-associated diarrhea in older inpatients.Methods A total of 163 older patients who were treated with wide-spectrum antibiotics at least three days during January 2014 to December 2015 were randomly divided into control and study group.In study group, 81 patients were administrated with oral Saccharomyces boulardii 500 mg twice a day for 21 days.The control group was of no intervention.Morbidity rate of antibiotic-associated diarrhea and Clostridium difficile-associated diarrhea, frequency and duration of diarrhea were recorded.Results The incidence of antibiotic-associated diarrhea in study group was significantly lower than that in control group [14.8%(12/81) vs 28.0%(23/82), P<0.05],whereas no difference was seen in the incidence of Clostridium difficile-associated diarrhea [3.7%(3/81) vs 4.9%(4/82), P>0.05] in two groups.The frequency and duration of diarrhea in the study group were significantly lower and shorter than those in control group[(4.3±1.7) times/day vs (6.9±2.0) times/day;(3.0±1.1) days vs (5.7±1.8) days, both P<0.01].Conclusion Saccharomyces boulardii may reduce the incidence of antibiotic-associated diarrhea therefore improving the symptom of diarrhea in older inpatients.
