Surgical treatment of severe, refractory hemorrhagic cystitis following allogeneic hematopoietic stem cell transplantation:a report of 17 patients

Feifei Tang; Xiaohui Zhang; Huan Chen; Yuhong Chen; Wei Han; Jingzhi Wang; Fengrong Wang; Yao Chen; Xiaojun Huang; Lanping XU

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Surgical treatment of severe, refractory hemorrhagic cystitis following allogeneic hematopoietic stem cell transplantation:a report of 17 patients

VernacularTitle:手术治疗异基因造血干细胞移植后难治性重度出血性膀胱炎17例分析
Author: Feifei TANG ; Xiaohui ZHANG ; Huan CHEN ; Yuhong CHEN ; Wei HAN ; Jingzhi WANG ; Fengrong WANG ; Yao CHEN ; Xiaojun HUANG ; Lanping XU
Keywords: Hematopoietic stem cell transplantation; allogeneic; Cystitis; Surgical treatment; operative
From: Chinese Journal of Internal Medicine 2017;56(6):414-418
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical effect and safety of surgical treatment for severe, refractory hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).Methods Patients with severe HC, who were admitted to Peking University Institute of Hematology from January 2010 to December 2015, were enrolled in this study.All patients were refractory to medical managements and received bladder surgery including mucous electrocoagulation and/or selective transcatheter arterial embolization.Results A total of 17 patients with severe HC (grade Ⅲ, n=5;grade Ⅳ, n=12) received surgical treatment, including 11 embolization and 18 mucous electrocoagulation.The median time from allo-HSCT to surgery was 107 d (46-179 d) and 75 d after HC.Eight patients only received embolization.Four patients only received mucous electrocoagulation.Five patients were given combined embolization and electrocoagulation.HC was cured in 11 patients, improved in 1 patient, which corresponded to a response rate of 70.6% and complete remission rate of 64.7%.Five patients didn′t respond to these methods.In patients with response, macroscopic hematuria disappeared 3 to 10 days after treatments whereas microscopic hematuria vanished after 25 to 32 days.Both procedures were well tolerated and no severe adverse effects were observed.Conclusion Surgery of bladder mucous electrocoagulation and/or selective arterial embolization are safe and effective for severe HC.