The diagnostic value of GGT combined with ultrasound found gallbladder abnormality in infants with biliary atresia
10.3760/cma.j.issn.1007-631X.2017.05.014
- VernacularTitle:谷氨酰转肽酶测定联合超声诊断先天性胆道闭锁
- Author:
Yuanyuan WEI
;
Yang CHEN
;
Ting GAO
;
Meiyun DING
;
Jianghua ZHAN
- Keywords:
Jaundice,obstructive;
Ultrasonography;
Bliliary atresia
- From:
Chinese Journal of General Surgery
2017;32(5):425-428
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate GGT in combination with B ultrasound for the diagnosis of biliary atresia (BA) infants suffering from obstructive jaundice.Methods A retrospective analysis was made on 69 sick infants including 55 BAs and 14 non-BAs as identified by intraoperative cholangiography.The preoperative laboratory GGT and ultrasound data were collected and analyzed.The sensitivity,specificity,positive predictive value,negative predictive value and accuracy were compared.Results BA patients had significantly higher GGT than Non-BA patients (t =-4.164,P ＜ 0.05).The sensitivity,specificity,positive predictive value,negative predictive value and accuracy of GGT ＞ 306 U/L were 69.1％,92.9％,97.4％,43.3％,73.9％,respectively.In BA group,abnormal gallbladder was significantly associated with proadening portal vein,broadening hepatic artery compared with Non-BA patients (x2 =9.995,P ＜0.05).The accuracy of abnormal gallbladder on ultrasound was 78.3％.When two method combined for the diagnosis of BA,the sensitivity,specificity,positive predictive value,negative predictive value were 92.7％,92.9％,98.1％ and 76.5％ and accuracy can reach 92.8％.Conclusions For obstructive jaundice infants with GGT ＞ 306 U/L and abdominal gallbladder ultrasound finding intraoperative cholangiography should be carried out to make definite diagnosis of BA.
