Serum IL-33 level and its correlation with TH1, TH2, TH17 and Treg cells in patients with unexplained recurrent spontaneous abortion
10.13602/j.cnki.jcls.2017.04.11
- VernacularTitle:原因不明复发性流产患者血清IL-33水平与TH1、TH2、TH17及Treg细胞间的关系
- Author:
Qianqian FEI
;
Jiayi DING
;
Weihong SHI
;
Hua JIN
;
Xiaofang TAN
;
Xiaobo CHEN
- Keywords:
unexplained recurrent spontaneous abortion;
IL-33;
helper T cell;
regulatory T cell
- From:
Chinese Journal of Clinical Laboratory Science
2017;35(4):281-284
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum IL-33 level and its association with TH1,TH2,TH17 and Treg cells in patients with unexplained recurrent spontaneous abortion(URSA).Methods Forty-six URSA patients and 40 healthy controls were enrolled.The proportions of TH1,TH2,TH17 and Treg cells in peripheral blood samples were determined by flow cytometry,and serum IL-33 levels by ELISA.Results The levels of serum IL-33 in URSA patients were significantly lower than that in healthy controls.The proportions of TH2 and Treg cells in URSA patients were significantly lower than that in healthy controls (P ＜ 0.05),while the proportions of TH 1 and TH 17 cells in URSA patients were significantly higher than that in healthy controls.Serum IL-33 levels were negatively correlated with the proportions of TH 1 and TH17 cells,and positively with that of TH2 cells,while no correlation with Treg cells.Conclusion Serum IL-33 levels decrease significantly in URSA patients,and are correlated with the proportions of TH1,TH2 and TH17 cells,indicating that IL-33 may be associated with TH1,TH2 and TH17 cells in URSA patients.
