Research on the relationship between fructose-1, 6-bisphosphatase and chemosensitivity of ovarian carcinoma
10.19401/j.cnki.1007-3639.2017.05.004
- VernacularTitle:糖代谢中关键酶果糖双磷酸酶-1与卵巢癌化疗敏感性关系的研究
- Author:
Haoran LI
;
Mengjiao LI
;
Fei LIU
;
Ziliang WANG
;
Xi CHENG
- Keywords:
Fructose-1;
6-bisphosphatase;
Ovarian neoplasms;
Cisplatin;
Chemosensitivity
- From:China Oncology
2017;27(5):340-344
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose: Epithelial ovarian carcinoma is the most malignant tumor in female reproductive system because of its resistance to chemotherapy. Fructose-1, 6-bisphosphatase (FBP1) is a rate-limiting enzyme in gluconeogenesis used to catalyze the hydrolysis of fructose-1, 6-bisphosphate to fructose-6-phosphate and inorganic phosphate, thereby inhibiting the effect of glycolysis in tumor cells. This study aimed to investigate the association between the expression of FBP1 and chemosensitivity. Methods: The expression level of FBP1 in ovarian cancer patients was measured by immunohistochemistry. Results: According to the results of immunohistochemistry in 209 ovarian carcinoma specimens, the percentage of positive FBP1 expression was about 49.3% (103/209). Loss of FBP1 was a negative factor of survival (42.6 months vs 62.1 months, P=0.003). Besides, patients who were sensitive to chemotherapy displayed significantly higher scores of FBP1 expression than patients who were resistant to therapy (P=0.007). Conclusion: The rate-limiting enzyme FBP1 in gluconeogenesis can be used as a biomarker for predicting the chemoresistance and prognosis of ovarian cancer patients.
