Chloride channels and ischemic stroke
10.3760/cma.j.issn.1673-4165.2017.03.017
- VernacularTitle:氯离子通道与缺血性卒中
- Author:
Xiang CAO
;
Yun XU
- Keywords:
Stroke;
Brain Ischemia;
Chloride Channels;
Muscle;
Smooth;
Vascular;
Myocytes;
Smooth Muscle;
Apoptosis;
Neuroprotective Agents
- From:
International Journal of Cerebrovascular Diseases
2017;25(3):285-288
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke is one of the diseases with the highest morbidity and disability.Hypertension is recognized as the most important independent risk factor for ischemic stroke.Vascular remodeling during the development of hypertension is the pathological basis of causing ischemic stroke.Studies have shown that vascular smooth muscle cell proliferation and apoptosis will lead to vascular remodeling.In addition,cerebral ischemia-reperfusion can result in neuronal damage and apoptosis.Recent research has shown that vascular remodeling and neuronal apoptosis are associated with chloride channels.At least 3 chloride channels including volume regulated chloride channel,calcium activated chloride channel and cystic fibrosis transmembrane conductance regulator are involved in these processes.This article reviews the roles of the 3 chloride channels in vascular remodeling,neuronal apoptosis,and ischemic stroke.
