The status and influencing factors of infusion-related adverse events in third-party cord blood stem cell infu-sion

VernacularTitle:第三方脐血输注不良反应现状及其影响因素研究
Author: Yin LU ; Xiaming ZHU ; Qin LI ; Jia CHEN ; Depei WU ; Yongchun LIANG ; Lili ZHOU ; Minghong LIU
Keywords: Cord Blood Stem Cell Transplantation; Adverse Reaction; Root Cause Analysis
From: Chinese Journal of Nursing 2017;52(5):576-580
CountryChina
Language:Chinese
Abstract: Objective To investigate the status and influencing factors of infusion-related adverse events in third-party cord blood stem cell infusion. Methods A total of 305 patients successfully underwent haploidentical stem cell transplantation combined with the third-party cord blood(CB) infusion,were recruited by convenience sampling from January 2013 to December 2015,in hematological department of a tertiary hospital in Suzhou. A self-developed questionnaire and adverse event assessment scale were used to investigate the influencing factors. Results The rate of infusion-related adverse events was 49.51%,81.82% were related to cardiovascular adverse events with the high-est rate of hypertension(76.14%). Logistic regression analysis showed that age(OR=1.030,95CI%:1.010-1.051),HLA matching between CB and receptor (OR=0.589,95%CI:0.413-0.838),thawed CB cell activity (OR=1.064,95%CI:1.015-1.115)were major influencing factors. Conclusion Nurses should pay attention to patients who are elderly,with low matching HLA and receive thawed CB product with high cell activities,and provide timely nursing care in advance.