Effects of incretin class of antidiabetic drugs on lipid metabolism in patients with type 2 diabetes and its mechanism

VernacularTitle:肠促胰素类降糖药对2型糖尿病患者脂代谢的影响及其作用机制
Author: Fei MAO ; Yiming LI
Keywords: Diabetes mellitus; type 2; Incretin; Lipid metabolism
From: Chinese Journal of Endocrinology and Metabolism 2017;33(5):435-437
CountryChina
Language:Chinese
Abstract: Chronic hyperglycemia is often accompanied by abnormal lipid metabolism, hypertension, low-grade systemic inflammation and oxidative stress.These factors increase the risk of cardiovascular disease(CVD)in type 2 diabetes mellitus(T2DM)patients.Comprehensive treatment of T2DM should emphasize the improvement of abnormal lipid metabolism, prevention of weight gain and reduction of the CVD risk in addition to proper glycemic control.Incretin, as a new hypoglycemic drug, has more advantages in improving glucose and lipid metabolism, finally to reduce cardiovascular risk.Through possible mechanisms including direct influence on liver lipid metabolism, change of fat mobilization and delay of gastric emptying, incretin shows positive influence on the lipid metabolic markers such as low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, triglycerides, and total cholesterol, while it improves glucose control.Thus, incretin plays an important role in the comprehensive management of type 2 diabetes mellitus.