Role of preoperative neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, prognostic nutritional index in the prognosis of patients with hepatitis B virus-related hepatocellular carcinoma after radical resection
10.3760/cma.j.issn.1007-631X.2017.05.016
- VernacularTitle:中性粒细胞与淋巴细胞比值和预后营养指数对乙肝相关性肝癌切除的预后意义
- Author:
Shaohu WANG
;
Yi CAO
;
Haoyang ZHANG
;
Can CHEN
;
Zhu XU
;
Qiucheng CAI
;
Lizhi LYU
;
Yi JIANG
- Keywords:
Carcinoma,hepatocellular;
Granulocytes;
Lymphocyte;
Nutritional assessment
- From:
Chinese Journal of General Surgery
2017;32(5):433-437
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of preoperative peripheral blood neutrophil to lymphocyte ratio (NLR),platelet to lymphocyte ratio (PLR),prognostic nutritional index (PNI) in the prognosis of patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after radical operation.Methods This is a retrospective study,involving 426 surgically resected hepatitis B related hepatocellular carcinoma cases in a single center from 2003 to 2012.Results Kaplan-Meier analysis showed patients in NLR ≤ 1.62 group achieve higher rate of recurrence-free and overall survival than that in the NLR ＞ 1.62 group,the difference was statistically significant (P ＜ 0.005);Also PNI ＞ 49.42 group showed higher rate of overall survival significantly than PNI≤49.42 group (P ＜ 0.005).The results of Cox regression multivariate analysis further suggested that both NLR ＞ 1.62 (HR 1.74,P =0.007) and PNI ≤49.42 (HR 0.70,P =0.021) were independent risk factors for overall survival,NLR ＞ 1.62 (HR 1.45,P =0.03) was also an independent risk factor for recurrence-free survival.Conclusion The preoperative NLR and PNI may be independent risk factors for prognosis of patients with HBV-related HCC after radical operation.
