Analysis of genetic mutation of UGT1A1 * 28 and UGT1A1 * 6 in renal transplant patients with unconjugated hyperbilirubinemia
10.3760/cma.j.issn.0254-1785.2017.02.010
- VernacularTitle:肾移植后非结合性高胆红素血症患者UGT1A1*28和*6基因突变的分析
- Author:
Zhihao YANG
;
Zhenshan DING
;
Guan ZHANG
;
Haixin CHEN
;
Pengmei LI
;
Xiaoxing WANG
;
Wangjun QIN
;
Xianglin ZHANG
- Keywords:
Kidney transplantation;
Gilbert's syndrome;
UGT1A1 * 6;
UGT1A1 * 28
- From:
Chinese Journal of Organ Transplantation
2017;38(2):108-111
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance and gene mutation profiles of renal transplant patients with unconjugated hyperbilirubinemia (Gilbert's syndrome).Methods Genomic DNA was extracted from peripheral blood samples of 8 renal transplant patients with Gilbert'S syndrome.UGT1A1 * 6 and UGT1A1 * 28 genotypes were identified through digital fluorescence molecular hybridization and DNA sequencing.Results There are 2 cases of UGT1A1 * 28 heterozygous mutant,3 cases of UGT1A1 * 6 homozygous mutant,2 case of UGT1A1 * 6 heterozygous mutant,1 case of UGT1A1 * 28 heterozygous mutant combined with UGT1A1 * 6 heterozygous mutant.Conclusion There is a higher heterozygous or homozygous gene mutation rate of UGT1A1 * 6 and UGT1A1 * 28 in renal transplant patients with Gilbert's syndrome.Genetic mutation of UGT1A1 * 6 and UGT1A1 * 28 may be the reason of Gilbert's syndrome after renal transplant.
