The effects of estrogen replacement therapy and local application of bisphosphonates on the implant osseointegration in ovariectomized rats

VernacularTitle:同时应用雌激素和二膦酸盐对骨质疏松大鼠种植体骨结合的累加效应
Author: Maiquan WANG ; Yunfeng LI
Keywords: Dental implant; Osteoporosis; Osseointegration
From: Journal of Practical Stomatology 2016;32(5):640-644
CountryChina
Language:Chinese
Abstract: Objective:To investigate the effect of local application of bisphosphonates(BPs) and systemic estrogen replacement therapy on the osseointergration of hydroxyapatite-coated implant in ovariectomized rats.Methods:12 weeks after ovariectomiy,each of the 20 female rats accepted 2 hydroxyapatite-coated implant screws in proximal tibiae,with and without immobilized BPs respectively on 2 sides.Half of the animals received subcutaneous injections of 17β-estradiol(E).Thus,there were 4 groups:control,estrogen (E),BPs and E + BPs.Tibiae with the implant screws were examined by μ-CT and push-out test was performed 12 weeks after implantation.Results:The bone volume ratio around screws and the percentage osteointegration in E + BPs group increased by 2.3-fold and 1.9-fold,and the push-out force by 3.3-fold respectively,compared to untreated controls.In group E the fixation of screws was also increased but less than that in group E + BPs.Conclusion:Systemic estrogen replacement therapy and locally immobilized BPs have additive effects on osseointergration of hydroxyapatite-coated implant screws in ovariectomized rats.