Dose-response relationship and muscle relaxant residual induced by rocuronium in children with cleft lip and palate repair
10.3969/j.issn.1001-3733.2016.05.026
- VernacularTitle:罗库溴铵用于小儿唇腭裂修复术的量效关系及肌松残余的观察
- Author:
Yinhui ZHOU
;
Dan CHENG
;
Wei ZHANG
- Keywords:
Rocuronium;
Cleft lip and palate in children;
Muscle relaxant residual
- From:
Journal of Practical Stomatology
2016;32(5):708-711
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of rocuronium in the intravenous anesthesia in children with cleft lip and palate repair.Methods:According to random number table,96 children with cleft lip and palate aged 1-3 years underwent general anesthesia for surgery were divided into 3 groups (n =32).The children in group A,B and C received intravenous injection of rocuronium at 0.6,0.9 and 1.2 mg/kg,respectively.The anesthesia effects were observed.Accelerometry (TOF-Watch(@) SX) was used to monitor neuromuscular transmission.Results:Intubating conditions ranged from good to excellent in all children.The onset time of anesthesia in Group C was significantly shorter(P ＜ 0.05),the duration of neuromuscular block was significantly longer in group C than in group A and B (P ＜ 0.05).The recovery index in group C was significantly longer than that in group A and B (P ＜ 0.05,A vs B,P ＞ 0.05).Muscle relaxant residual incidence in group C was higher than that in group A and B (P ＜ 0.05,A vs B,P ＞ 0.05).Conclusion:Rocuronium at 0.6 mg/kg or 0.9 mg/kg are effective for excellent tracheal intubation,with faster onset time and recovery time,low incidence of postoperative residual curarization(PORC) in children with cleft lip and palate repair.
