Effects of Huangqi Powder on femur and tibia in rats with glucocorticoid-induced osteoporosis
10.3969/j.issn.1001-1528.2017.06.001
- VernacularTitle:黄芪散对糖皮质激素性骨质疏松大鼠股骨和胫骨的影响
- Author:
Fang WANG
;
Jun CHEN
;
Xuxin ZENG
;
Jiahao ZHANG
;
Dandan LIANG
;
Weimin LI
- Keywords:
glucocorticoid-induced osteoporosis;
Huangqi Powder (HQP);
bone biomechanics;
bone histomorphometry;
femur;
tibia
- From:
Chinese Traditional Patent Medicine
2017;39(6):1109-1114
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the influence of Huangqi Powder (Puerariae lobatae Radix,Astragali Radix,Mori Cortex) on femur and tibia in rats with glucocorticoid-induced osteoporosis (GIOP).METHODS Thirty one-month-old male SD rats were divided into three groups by randomized block design,which were control group (normal saline),prednisone group (3.5 mg/kg prednisone acetate),Huangqi Powder group (clinical adult dosage).Experimental test was maintained for one hundred and twenty days.Double fluorochrome labeling with calcein was performed before necropsy;bone resorption and bone formation index were determined by using blood serum;the femur structural and material mechanics were analyzed by using bone biomechanics method.The cancellous bone of proximal tibial and the cortical bone of tibial shaft static parameter and dynamic parameter were analyzed by bone histomorphometry method.RESULTS Huangqi Powder had no obvious improving effects on bone biomechanics and bone static parameter,but could increas the area,width and number of the proximal tibia bone trabecular.Mark perimeter percentage and mineralization rate of deposition could be increased.CONCLUSION Huangqi Powder can significantly increase proximal tibia cancellous bone mass and enhance bone trabecula structure of glucocorticoid-induced osteoporosis rats.
