Experimental Research Progress of Wnt Signaling Pathway in Spinal Cord Injury Repair (review)
10.3969/j.issn.1006-9771.2017.06.005
- VernacularTitle:Wnt信号通路在脊髓损伤修复中作用的实验研究进展
- Author:
Xianan MAN
;
Jianer CHEN
- Keywords:
Wnt signaling pathway;
spinal cord injury;
neural stem cells;
Wnt/β-catenin pathway;
review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2017;23(6):645-648
- CountryChina
- Language:Chinese
-
Abstract:
Wnt signaling pathway is one of the important signal transduction systems that involved in regulating nervous system devel-opment, which plays an important role in axonal regeneration, neural stem cell proliferation and differentiation into neurons and inhibition of differentiation into glial cells. After spinal cord injury, multiple Wnt protein expresses around the injury site, and some proteins of the Wnt family play an important role in spinal cord injury repair, in which the activation of Wnt/β-catenin signaling pathway is necessary for spinal cord regeneration after spinal cord injury.
