Preparation of transdermal drug delivery system of carbon nanotubes graft ginsenosides Rb1 and Rb2 nanoemulsion

VernacularTitle:碳纳米管结合人参皂苷Rb1、Rb2纳米乳经皮给药系统的制备
Author: Chenhong ZENG ; Zheng WANG ; Chong CHEN ; Li WEI
Keywords: carbon nanotubes; ginsenoside Rb1; ginsenoside Rb2; nanoemulsion; transdermal drug delivery system; antioxidant activity
From: Chinese Traditional Patent Medicine 2017;39(6):1161-1164
CountryChina
Language:Chinese
Abstract: AIM To prepare the transdermal drug delivery system of carbon nanotubes graft ginsenosides Rb1 and Rb2 nanoemulsion.METHODS After 0.5％ carbon nanotubes' dispersion into the prepared nanoemulsion,the combination state was observed under transmission electron microscope.The skin irritation and transdermal mechanism of this drug delivery system were investigated.Then the UVA-damaged mouse skin model was established to evaluate the antioxidant activity.RESULTS Carbon nanotubes had strong adsorption to nanoemulsion,together with the formation of drug storage cavern in epidermis,thus increased the transdermal osmotic quantities of ginsenosides Rb1 and Rb2.The SOD activity in mouse skin tissue in the drug delivery system group was higher than that in the model group and the nanoemulsion group (P ＜0.01),and the MDA content was significantly decreased (P ＜ 0.01).CONCLUSION The transdermal drug delivery system of carbon nanotubes graft ginsenosides Rb1 and Rb2 nanoemulsion can make drugs play an antioxidant role because of its less irritation to skin and better skin permeability.