Amelioration of low dose enteral nutrition on the intestinal barrier and systemic inflammation for septic shock patients combined with acute gastrointestinal injury
10.16151/j.1007-810x.2017.03.005
- VernacularTitle:小剂量肠内营养对脓毒性休克伴急性胃肠道损伤病人肠屏障及系统性炎症的改善作用
- Author:
Luwei YE
;
Zhigang WANG
;
Shifang HUANG
;
Jiangjiang GONG
;
Longzhu LI
;
Xinglong ZHENG
;
Haiyan HUANG
;
Liyan CUI
;
Minjie ZHANG
- Keywords:
Septic shock;
Enteral nutrition;
Acute gastrointestinal injury;
Intestinal barrier function;
Inflammation
- From:Parenteral & Enteral Nutrition
2017;24(3):143-145,149
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the value of low dose enteral nutrition (EN) in treatment of septic shock combined with acute gastrointestinal injury Ⅲ (AGI Ⅲ).Methods:Clinical data of septic shock patients combined with AGI Ⅲ admitted at our hospital were analyzed.Patients were divided into two groups according to the nutrition therapy they received:treatment group (EN,n =41) and control group (no EN,n =46).The mortality and ICU hospital stays were collected.The intestinal barrier,inflammatory cytokines,and oxidative stress were evaluated before and after EN treatment.Results:For patients in the treatment group,the dosages of EN ranged from 200 to 410 kcal/d,with the median dose of 350 kcal/d.No significant differences were found on death rates between the two groups (24.4％vs 32.6％,P =0.398).Patients in the treatment group had shorter ICU hospital stays than those of the control group (11.8 ± 3.7 vs 16.2 ± 5.3,P ＜0.01).After one week EN treatment,patients in the treatment group had lower levels of CRP,IL-6,TNF-α,diamine oxidase,endotoxin and D-lactate than those of the control group (P ＜ 0.05).Conclusion:For septic shock patients combined with AGI Ⅲ,low dose EN can improve the intestinal barrier function and systemic inflammatory responses.
