Progress in the biological effects of muscle-specific microRNAs on muscle contraction and relaxation

VernacularTitle:肌细胞特异性microRNAs对收缩舒张生物学效应调控机制的研究进展
Author: Tingting DUAN
Keywords: muscle-specific microRNAs; smooth muscle; skeletal muscle; cardiac muscle; mechanism of muscle contraction and relaxation
From: Fudan University Journal of Medical Sciences 2017;44(3):385-391
CountryChina
Language:Chinese
Abstract: Muscle-specific microRNAs (myomiRs) are a class of small endogenous non-coding RNAs that expressed specifically in the muscle tissue.By negatively regulating related gene expression at posttranslational level,they participate in a variety of biological processes and affects the occurrence and development of diseases.The occurrence and development of muscle-related diseases,such as chronic obstructive pneumonia disease,hypertrophic cardiomyopathy and so on,induce the expression changes of myomiRs and downstream target genes.The effects of myomiRs on the muscle contraction will affect the development of the disease.This paper will review the biological effects of common myomiRs,such as miR-1,miR-133,miR-206,miR-208 and miR-499 in muscle contraction and relaxation,including striated and non-striated muscle.Better understanding of the effects of myomiRs on the biological effects of muscle contraction and relaxation will provide a new idea for the treatment of muscle-related diseases.