Effects of gender on screening value of aldosterone-renin ratio for primary aldosteronism
10.11855/j.issn.0577-7402.2017.01.10
- VernacularTitle:性别对ARR在原发性醛固酮增多症筛查中的价值的影响
- Author:
Yeqiong SONG
;
Lin WANG
;
Jie ZHU
;
Xiaomeng JIA
;
Ping PANG
;
Nan JIN
;
Li ZANG
;
Guoqing YANG
;
Weijun GU
;
Jin DU
;
Xianling WANG
;
Qinghua GUO
;
Lijuan YANG
;
Zhaohui LV
;
Jianming BA
;
Jingtao DOU
;
Yiming MU
- Keywords:
hyperaldosteronism;
sex factor;
posture
- From:
Medical Journal of Chinese People's Liberation Army
2017;42(1):52-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the potential influence of gender on screening value of aldosterone-renin ratio (ARR) for primary aldosteronism (PA).Methods The biochemical parameters were collected of 451 PA patients and 300 essential hypertension (EH) patients who were diagnosed in the General Hospital of PLA from 1992 to 2014. Each group was then divided into two groups by gender. The clinical characteristics were compared and then the receiver operating characteristic curve (ROC) was conducted to evaluate the best cut-off value.Results The plasma aldosterone concentration (PAC), serum sodium and ARR were much higher, but the plasma rennin activity (PRA), serum potassium and BMI were much lower in PA patients than in EH patients (P<0.01), and no significant difference existed between the two groups in age, duration of hypertension and blood pressure. The PRA was obviously lower in males than in females either in PA or in EH patients, but no signicantcant difference existed between males and females in PAC (P>0.05). The best cut-off value of ARR in male PA patients was 19.11, the relevant area under the curve (AUC) was 0.968, the sensitivity and specicantcity was 92.44% and 93.08%, and the Youden index (YI) was 0.86. The best cut-off value of ARR in female PA patients was 27.26, with AUC 0.956, sensitivity 92.07%, specicantcity 90.00% and YI 0.82, respectively. If the cut-off value was set at 27.26 in males, the specicantcity would rise a little, but the sensitivity and YI would sharply decrease. Similarly, the sensitivity would increase a little but the specicantcity and YI would fall substantially if the cut-off value in females was set at 19.11. The best cut-off value of ARR in men was smaller than the ocantcial value recommended by guidelines.Conclusion Gender is an important factor should be considered while ARR is used in PA screening, and the cut-off value of ARR in screening female PA patients should be setting higher.
