Relevance Epistasis Network of Gastritis for Intra-chromosomes in the Korea Associated Resource (KARE) Cohort Study.
- Author:
Hyun Hwan JEONG
1
;
Kyung Ah SOHN
Author Information
- Publication Type:Original Article
- Keywords: gastritis; genome-wide association study; KARE; mutual information; relevance network; single-nucleotide polymorphism
- MeSH: Case-Control Studies; Cohort Studies*; Gastritis*; Genome-Wide Association Study; Helicobacter pylori; Korea; Polymorphism, Single Nucleotide
- From:Genomics & Informatics 2014;12(4):216-224
- CountryRepublic of Korea
- Language:English
- Abstract: Gastritis is a common but a serious disease with a potential risk of developing carcinoma. Helicobacter pylori infection is reported as the most common cause of gastritis, but other genetic and genomic factors exist, especially single-nucleotide polymorphisms (SNPs). Association studies between SNPs and gastritis disease are important, but results on epistatic interactions from multiple SNPs are rarely found in previous genome-wide association (GWA) studies. In this study, we performed computational GWA case-control studies for gastritis in Korea Associated Resource (KARE) data. By transforming the resulting SNP epistasis network into a gene-gene epistasis network, we also identified potential gene-gene interaction factors that affect the susceptibility to gastritis.
