The role of RyR2 phosphorylation in heart failure
10.3969/j.issn.1672-8467.2017.03.018
- VernacularTitle:RyR2磷酸化在心力衰竭中的作用
- Author:
Huihua CHEN
- Keywords:
ryanodine receptor;
heart failure;
protein kinase A;
calcium/calmodulin dependent protein kinase Ⅱ
- From:
Fudan University Journal of Medical Sciences
2017;44(3):359-362
- CountryChina
- Language:Chinese
-
Abstract:
Heart failure is mainly characterized by myocardial systolic dysfunction,which is based on excitement-contraction coupling on the cellular level,and calcium (Ca2+) signaling plays a very important role in this process.The ryanodine receptor (RyR)/calcium release channel on the sarcoplasmic reticulum (SR) is the major Ca2+ source of required for cardiac muscle excitation contraction coupling.RyR2 phosphorylation is the basis of SR calcium release,and RyR2 phosphorylation is mainly controled by protein kinase A (PKA) and calcium/calmodulin dependent protein kinase Ⅱ (CaMK Ⅱ).Although widely research in this area,excessive activation of RyR2 phosphorylation involved in the pathogenesis of heart failure are still controversial,which is discussed in this review.
