The impact and potential mechanism of glucagon-like peptide-1 on bone metabolism
10.3969/j.issn.1672-8467.2017.03.020
- VernacularTitle:胰高血糖素样肽-1对骨代谢的影响和潜在机制
- Author:
Chenhe ZHAO
- Keywords:
glucagon-like peptide-1;
osteogenesis;
bone resorption;
osteoporosis;
diabetes mellitus
- From:
Fudan University Journal of Medical Sciences
2017;44(3):369-373
- CountryChina
- Language:Chinese
-
Abstract:
Glucagon-like peptide-1 (GLP-1) receptor agonists are a novel type of drugs for type 2 diabetes mellitus (T2DM),and its impact on bone metabolism has drawn great attention nowadays.This review reveals the impact and potential mechanism of GLP-1 on bone metabolism:GLP-1 enhances bone mineral density and improves bone quality and it may act on bone by promoting bone formation,inhibiting bone resorption and affecting the coupling mechanism of them in order to play its role in bone metabolism.
