"Research advances in ""treatment resistance"" of non-operative therapies for hepatocellular carcinoma"
10.3969/j.issn.1672-8467.2017.03.021
- VernacularTitle:肝癌非手术治疗“治疗抵抗”的研究进展
- Author:
Gang DONG
- Keywords:
hepatocellular carcinoma;
non-surgical treatment;
treatment resistance
- From:
Fudan University Journal of Medical Sciences
2017;44(3):374-379,394
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) has the characteristics of high malignancy and poor prognosis.Liver transplantation and hepatectomy are applied in a small portion of patients with localized disease.Due to the hidden onset,HCC is usually diagnosed at an intermediate-advanced stage or with advancing cirrhosis.In most cases,various non-operative treatments are applied,including transarterial chemoembolization (TACE),local ablation,radiotherapy and molecular targeted drugs.The therapeutic effect of non-surgical treatments is not always ideal because the incidence of recurrence and metastasis after treatment is high.It also may be associated with treatment resistance of HCC to non-operative treatments.Optimizing the current management schemes has great significance in improving patients' quality of life and prolonging their survival.
