Expression of microtubule-associated protein 2 correlates with better prognosis of pancreatic neuroendocrine tumors

VernacularTitle:微管相关蛋白2在胰腺神经内分泌肿瘤组织中的表达及预后意义
Author: Tiantian SONG ; Yu XIAO ; Chunmei BAI ; Naishi LI ; Jie CHEN ; Dachun ZHAO ; Yuli SONG ; Kaizhou JIN ; Liming ZHU ; Run YU ; Xianjun YU ; Yuanjia CHEN
Keywords: microtubule-associated protein 2; pancreatic neuroendocrine tumors; prognosis
From: Chinese Journal of Clinical Oncology 2017;44(11):532-538
CountryChina
Language:Chinese
Abstract: Objective: To determine whether microtubule-associated protein 2 (MAP2) and microtubule-associated protein 1B (MAP1B) could be prognostic biomarkers for patients with pancreatic neuroendocrine tumors (PNETs). Methods:With immunohisto-chemical staining, the expressions of MAP2 and MAP1B were examined in 193 and 120 primary tumors and peritumoral tissues, re-spectively. Then, the relationship between the expression of each protein and clinicopathological characteristics, including prognosis was analyzed. Results:MAP2 and MAP1B were expressed in 88 of 193 (45.6%) and 77 of 120 (64.2%) tumors, respectively. The expres-sion of MAP2 was significantly associated with the favorable overall survival of patients with PNETs (P=0.012). Moreover, MAP2 expres-sion was associated with the improved overall survival in a subset of patients with stageⅡand stageⅢtumors (P=0.017). The MAP1B expression did not correlate with other clinicopathological features and prognosis. Conclusion:MAP2 could be a novel, independent prognostcbiomarker for PNETs.