Expression of PD-L1 and its prognostic role in patients with esophageal squamous cell carcinoma
10.13315/j.cnki.cjcep.2017.04.001
- VernacularTitle:食管鳞状细胞癌中PD-L1的表达及其预后意义
- Author:
Yalan LIU
;
Dongxian JIANG
;
Yingyong HOU
;
Yifan XU
;
Jieakesu SU
;
Haiying ZENG
;
Feng GAO
;
Xiaolei ZHANG
;
Chen XU
- Keywords:
esophageal neoplasms;
squamous cell carcinoma;
PD-L1 expression;
clinical stage;
prognostic marker
- From:
Chinese Journal of Clinical and Experimental Pathology
2017;33(4):355-359
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To analyze the correlations between PD-L1 expression and clinicopathological factors and their prognostic values in esophageal squamous cell carcinoma (ESCC) patients.Methods PD-L1 expression in the primary tumors from 253 patients with ESCC was evaluated using tissue microarray and immunohistochemistry (IHC).PD-L1 positivity was defined as positive staining of 1％ and 5％ tumor cells.Survival curves were constructed by using the Kaplan-Meier method.Univariate and multivariate Cox proportional hazard regression models were performed to identify associations with outcome variables.Results Overall,tumoral PD-L1 expression was potentially associated with favorable DFS and OS.When the patients were stratified into stage Ⅰ + Ⅱ (60.9％,154/253) and stage Ⅲ + Ⅳa (39.1％,99/253),the prognostic role was not consistent.In patients with stage Ⅰ + Ⅱ disease,tumoral PD-L1 expression was associated with better DFS and OS upon multivariate analysis (1％ as the cutoff:P =0.046 and 0.021,5％ as the cutoff:P=0.011 and0.004).However,PD-L1 expression was not correlated with prognosis in patients with stage Ⅲ + Ⅳa disease (1％ as the cutoff:P =0.586 and 0.682,5％ as the cutoff:P =0.807 and 0.620).Conclusion The prognostic role of tumoral PDL expression is variable in different stages of ESCC,and tumoral PDL expression is an independent favorable predictor in ESCC patients with Stage Ⅰ-Ⅱ disease,but not in stage Ⅲ-Ⅳa or lymph node metastasis.
