Expression of CtBP1, Zeb1, Zeb2 and E-cadherin in cholangiocarcinoma and their clinical significance
10.13315/j.cnki.cjcep.2017.04.003
- VernacularTitle:胆管细胞癌中CtBP1、Zeb1、Zeb2与E-cadherin蛋白的表达及临床意义
- Author:
Jie HU
;
Lihui BIAN
;
Xiaoyu WANG
;
Yueli YANG
;
Xiaoling ZHANG
;
Shengjun XIAO
- Keywords:
liver neoplasms;
cholangiocarcinoma;
Zeb1;
Zeb2;
CtBP1;
E-cadherin
- From:
Chinese Journal of Clinical and Experimental Pathology
2017;33(4):365-369
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of transcriptional suppressor CtBP1,Zeb1,Zeb2 and their target gene E-cadherin,and their significance in cholangiocarcinoma.Methods The expression of CtBP1,Zeb1,Zeb2 and E-cadherin proteins in cholangiocarcinoma and the paired non-neoplastic tissue array were detected by the immunohistohemical staining.Results The positive rates of CtBP1 expression in cholangiocarcinoma and the paired non-neoplastic tissue were 44.44％ and 17.86％,these of Zeb2 were 34.92％ and 10.71％,and these of E-cadherin were 50.79％ and 100％,respectively.The differences between the groups were statistically significant (all P ＜ 0.05).There was only one case with expression of Zeb1 in cholangiocarcinoma,but no expression in the paired non-neoplastic tissue.CtBP1 was correlated with the degree of differentiation of cholangiocarcinoma (P ＜ 0.05).Ecadherin was related to the differentiation degree,and distant metastasis of cholangiocarcinoma (all P ＜ 0.05).The E-cadherin expression was negatively correlated with CtBP1 and Zeb2 (r =-0.034,-0.029,all P ＜ 0.05).The Zeb2 expression was positively correlated with CtBP1 (r =0.228,P =0.005).Conclusion CtBP1,Zeb2 and E-cadherin express abnormally in cholangiocarcinoma.CtBP1,Zeb2 may be involved in the regulation of E-cadherin expression.Joint detection of CtBP1 and Ecadherin is expected to be a reference index to evaluate the malignant biological behavior of cholangiocarcinoma.
